The polymeric mucin Muc5ac is required for allergic airway hyperreactivity

In asthma, airflow obstruction is thought to result primarily from inflammation-triggered airway smooth muscle (ASM) contraction. However, anti-inflammatory and smooth muscle-relaxing treatments are often temporary or ineffective. Overproduction of the mucin MUC5AC is an additional disease feature t...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Evans, Christopher M., Raclawska, Dorota S., Ttofali, Fani, Liptzin, Deborah R., Fletcher, Ashley A., Harper, Daniel N., McGing, Maggie A., McElwee, Melissa M., Williams, Olatunji W., Sanchez, Elizabeth, Roy, Michelle G., Kindrachuk, Kristen N., Wynn, Thomas A., Eltzschig, Holger K., Blackburn, Michael R., Tuvim, Michael J., Janssen, William J., Schwartz, David A., Dickey, Burton F.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4333679/
https://ncbi.nlm.nih.gov/pubmed/25687754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7281
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