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The nature of telomere fusion and a definition of the critical telomere length in human cells

The loss of telomere function can result in telomeric fusion events that lead to the types of genomic rearrangements, such as nonreciprocal translocations, that typify early-stage carcinogenesis. By using single-molecule approaches to characterize fusion events, we provide a functional definition of...

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Bibliografske podrobnosti
Main Authors: Capper, Rebecca, Britt-Compton, Bethan, Tankimanova, Maira, Rowson, Jan, Letsolo, Boitelo, Man, Stephen, Haughton, Michele, Baird, Duncan M.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1993879/
https://ncbi.nlm.nih.gov/pubmed/17908935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.439107
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