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Role of Active Site Tyrosines in Dynamic Aspects of DNA Binding by AP endonuclease
AP endonuclease (AP endo), a key enzyme in repair of abasic sites in DNA, makes a single nick 5′ to the phosphodeoxyribose of an abasic site (AP-site). We recently proposed a novel mechanism, whereby the enzyme uses a key tyrosine (Tyr(171)) to directly attack the scissile phosphate of the AP-site....
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1991299/ https://ncbi.nlm.nih.gov/pubmed/17218168 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2006.11.004 |
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