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Enzymatic mechanism of human apurinic/apyrimidinic endonuclease against a THF AP site model substrate
The endonucleolytic activity of human apurinic/apyrimidinic endonuclease (AP endo) is a major factor in the maintenance of the integrity of the human genome. There are estimates that this enzyme is responsible for eliminating as many as 10(5) potentially mutagenic and genotoxic lesions from the geno...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2731572/ https://ncbi.nlm.nih.gov/pubmed/19123919 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8016137 |
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