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Role of the catalytic metal during polymerization by DNA polymerase lambda
The incorporation of dNMPs into DNA by polymerases involves a phosphoryl transfer reaction hypothesized to require two divalent metal ions. Here we investigate this hypothesis using as a model human DNA polymerase λ (Pol λ), an enzyme suggested to be activated in vivo by manganese. We report the cry...
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| Glavni autori: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2007
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1989765/ https://ncbi.nlm.nih.gov/pubmed/17475573 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dnarep.2007.03.005 |
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