Wordt geladen...

HIGH-THROUGHPUT SCREENING FOR NOVEL HUMAN LYSOSOMAL BETA-N-ACETYL HEXOSAMINIDASE INHIBITORS ACTING AS PHARMACOLOGICAL CHAPERONES

The Adult forms of Tay-Sachs (ATSD) and Sandhoff (ASD) diseases result when the activity levels of human β-hexosaminidase A (Hex) fall below ~10% of normal, due to mutations that destabilize the native folded form of the enzyme in the endoplasmic reticulum (ER). The native fold not only conveys acti...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Tropak, Michael B., Blanchard, Jan, Withers, Stephen G., Brown, Eric, Mahuran, Don
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2007
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1989145/
https://ncbi.nlm.nih.gov/pubmed/17317569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2006.12.006
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!