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Prediction of individual genetic risk to disease from genome-wide association studies

Empirical studies suggest that the effect sizes of individual causal risk alleles underlying complex genetic diseases are small, with most genotype relative risks in the range of 1.1–2.0. Although the increased risk of disease for a carrier is small for any single locus, knowledge of multiple-risk a...

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Bibliografski detalji
Glavni autori: Wray, Naomi R., Goddard, Michael E., Visscher, Peter M.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2007
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1987352/
https://ncbi.nlm.nih.gov/pubmed/17785532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.6665407
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