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Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase

Activation of the c-Abl protein tyrosine kinase by certain DNA-damaging agents contributes to down-regulation of Cdk2 and G(1) arrest by a p53-dependent mechanism. The present work investigates the potential role of c-Abl in apoptosis induced by DNA damage. Transient transfection studies with wild-t...

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Autori principali: Yuan, Zhi-Min, Huang, Yinyin, Ishiko, Takatoshi, Kharbanda, Surender, Weichselbaum, Ralph, Kufe, Donald
Natura: Artigo
Lingua:Inglês
Pubblicazione: The National Academy of Sciences of the USA 1997
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC19809/
https://ncbi.nlm.nih.gov/pubmed/9037071
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