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Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase

Activation of the c-Abl protein tyrosine kinase by certain DNA-damaging agents contributes to down-regulation of Cdk2 and G(1) arrest by a p53-dependent mechanism. The present work investigates the potential role of c-Abl in apoptosis induced by DNA damage. Transient transfection studies with wild-t...

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Gespeichert in:
Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Yuan, Zhi-Min, Huang, Yinyin, Ishiko, Takatoshi, Kharbanda, Surender, Weichselbaum, Ralph, Kufe, Donald
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 1997
Schlagworte:
Biological Sciences
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19809/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9037071/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.4.1437
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