Macrophage-specific transgenic expression of cholesteryl ester hydrolase significantly reduces atherosclerosis and lesion necrosis in Ldlr(–/–) mice

Accumulation of cholesteryl esters (CEs) in macrophage foam cells, central to atherosclerotic plaque formation, occurs as a result of imbalance between the cholesterol influx and efflux pathways. While the uptake, or influx, of modified lipoproteins is largely unregulated, extracellular acceptor-med...

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Bibliographic Details
Main Authors: Zhao, Bin, Song, Jingmei, Chow, Woon N., St. Clair, Richard W., Rudel, Lawrence L., Ghosh, Shobha
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2007
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1978419/
https://ncbi.nlm.nih.gov/pubmed/17885686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI30485
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