1-Methylnicotinamide (MNA), a primary metabolite of nicotinamide, exerts anti-thrombotic activity mediated by a cyclooxygenase-2/prostacyclin pathway

BACKGROUND AND PURPOSE: 1-methylnicotinamide (MNA) has been considered to be an inactive metabolite of nicotinamide. Here we assessed the anti-thrombotic activity of MNA in vivo. EXPERIMENTAL APPROACH: Antithrombotic action of MNA was studied in normotensive rats with extracorporeal thrombus formati...

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Autors principals: Chlopicki, S, Swies, J, Mogielnicki, A, Buczko, W, Bartus, M, Lomnicka, M, Adamus, J, Gebicki, J
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2007
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1978255/
https://ncbi.nlm.nih.gov/pubmed/17641676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0707383
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