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Farnesyltransferase inhibitors inhibit T-cell cytokine production at the posttranscriptional level

Several cytoplasmic proteins, such as GTPases of the Ras family, containing a C-terminal CAAX motif are prenylated by farnesyltransferase to facilitate localization to cellular membranes where activation occurs. Farnesyltransferase inhibitors (FTIs) interfere with this farnesylation process, thereby...

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Bibliografische gegevens
Hoofdauteurs: Marks, Reinhard E., Ho, Allen W., Robbel, Christian, Kuna, Todd, Berk, Seth, Gajewski, Thomas F.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Hematology 2007
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1976355/
https://ncbi.nlm.nih.gov/pubmed/17545504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-06-031088
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