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Farnesyltransferase inhibitors inhibit T-cell cytokine production at the posttranscriptional level
Several cytoplasmic proteins, such as GTPases of the Ras family, containing a C-terminal CAAX motif are prenylated by farnesyltransferase to facilitate localization to cellular membranes where activation occurs. Farnesyltransferase inhibitors (FTIs) interfere with this farnesylation process, thereby...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society of Hematology
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1976355/ https://ncbi.nlm.nih.gov/pubmed/17545504 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-06-031088 |
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