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Discovery of Heterobicyclic Templates for Novel Metabotropic Glutamate Receptor Subtype 5 Antagonists

Investigation of a series of heterobicyclic compounds with essential pharmacophoric features of the metabotropic glutamate receptor 5 (mGluR5) antagonists MPEP and MTEP provided novel structural templates with sub-micromolar affinities at the mGluR5.

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Autors principals: Kulkarni, Santosh S., Newman, Amy Hauck
Format: Artigo
Idioma:Inglês
Publicat: 2007
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1973162/
https://ncbi.nlm.nih.gov/pubmed/17446071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.03.066
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