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Structure–Activity Relationships Comparing N-(6-Methylpyridin-yl)-Substituted Aryl Amides to 2-Methyl-6-(substituted-arylethynyl)pyridines or 2-Methyl-4-(substituted-arylethynyl)thiazoles as Novel Metabotropic Glutamate Receptor Subtype 5 Antagonists

The metabotropic glutamate receptor subtype 5 (mGluR5) has been implicated in anxiety, depression, pain, mental retardation, and addiction. The potent and selective noncompetitive mGluR5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP, 1) has been a critically important tool used to further eluc...

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Detalhes bibliográficos
Main Authors: Kulkarni, Santosh S., Zou, Mu-Fa, Cao, Jianjing, Deschamps, Jeffrey R., Rodriguez, Alice L., Conn, P. Jeffrey, Newman, Amy Hauck
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2894482/
https://ncbi.nlm.nih.gov/pubmed/19445453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm900172f
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