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Trans-splicing to Spliceosomal U2 snRNA Suggests Disruption of Branch Site-U2 Pairing During pre-mRNA Splicing

Pairing between U2 snRNA and the branch site of spliceosomal introns is essential for spliceosome assembly and is thought to be required for the first catalytic step of splicing. We have identified an RNA comprising the 5’ end of U2 snRNA and the 3’ exon of the ACT1-CUP1 reporter gene, resulting fro...

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Bibliographic Details
Main Authors: Smith, Duncan J., Query, Charles C., Konarska, Maria M.
Format: Artigo
Language:Inglês
Published: 2007
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1973159/
https://ncbi.nlm.nih.gov/pubmed/17588521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.05.020
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