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Competition between the ATPase Prp5 and branch region–U2 snRNA pairing modulates the fidelity of spliceosome assembly
ATPase-facilitated steps during spliceosome function have been postulated to afford opportunities for kinetic proof-reading. Spliceosome assembly requires the ATPase Prp5p, whose activity might thus impact fidelity during initial intron recognition. Using alanine mutations in S. cerevisiae Prp5p we...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2007
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2246091/ https://ncbi.nlm.nih.gov/pubmed/18082608 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2007.09.022 |
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