Changes in the V3 Region of gp120 Contribute to Unusually Broad Coreceptor Usage of an HIV-1 Isolate from a CCR5 Δ32 Heterozygote

Heterozygosity for the CCR5 Δ32 allele is associated with delayed progression to AIDS in human immunodeficiency virus type 1 (HIV-1) infection. Here we describe an unusual HIV-1 isolate from blood of an asymptomatic individual who was heterozygous for the CCR5 Δ32 allele and had reduced levels of CC...

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Main Authors: Gorry, Paul R., Dunfee, Rebecca L., Mefford, Megan E., Kunstman, Kevin, Morgan, Tom, Moore, John P., Mascola, John R., Agopian, Kristin, Holm, Geoffrey H., Mehle, Andrew, Taylor, Joann, Farzan, Michael, Wang, Hui, Ellery, Philip, Willey, Samantha J., Clapham, Paul R., Wolinsky, Steven M., Crowe, Suzanne M., Gabuzda, Dana
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1973138/
https://ncbi.nlm.nih.gov/pubmed/17239419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2006.11.025
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