A bispecific monoclonal antibody against methotrexate and a human tumour associated antigen augments cytotoxicity of methotrexate-carrier conjugate.

A bispecific monoclonal antibody, reactive with methotrexate (MTX) and a tumour associated antigen (gp72) has been produced by fusing spleen cells from MTX immunised mice with 791T/36/3 (anti-gp72) hybridoma. The hybrid antibody was purified from anti-MTX and anti-gp72 antibodies present in the hybr...

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Main Authors: Pimm, M. V., Robins, R. A., Embleton, M. J., Jacobs, E., Markham, A. J., Charleston, A., Baldwin, R. W.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1990
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1971384/
https://ncbi.nlm.nih.gov/pubmed/2331436
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