Recombinant ricin toxin A chain cytotoxicity against carcinoembryonic antigen expressing tumour cells mediated by a bispecific monoclonal antibody and its potentiation by ricin toxin B chain.

A bispecific monoclonal antibody recognising both carcinoembryonic antigen (CEA) and ricin toxin A chain (RTA) was tested for its ability to target recombinant RTA (r-RTA) to CEA-expressing tumour cells, alone and in combination with ricin B chain (RTB). The antibody, 636 (Robins et al., 1990), indu...

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Hauptverfasser: Embleton, M. J., Charleston, A., Robins, R. A., Pimm, M. V., Baldwin, R. W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 1991
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1972402/
https://ncbi.nlm.nih.gov/pubmed/2039690
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