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Protean agonism at histamine H(3) receptors in vitro and in vivo
G protein-coupled receptors (GPCRs) are allosteric proteins that adopt inactive (R) and active (R(*)) conformations in equilibrium. R(*) is promoted by agonists or occurs spontaneously, leading to constitutive activity of the receptor. Conversely, inverse agonists promote R and decrease constitutive...
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| Asıl Yazarlar: | , , , , , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
National Academy of Sciences
2003
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC196931/ https://ncbi.nlm.nih.gov/pubmed/12960366 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1932276100 |
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