Distinct pharmacology of rat and human histamine H(3) receptors: role of two amino acids in the third transmembrane domain

Starting from the sequence of the human histamine H(3) receptor (hH(3)R) cDNA, we have cloned the corresponding rat cDNA. Whereas the two deduced proteins show 93.5% overall homology and differ only by five amino acid residues at the level of the transmembrane domains (TMs), some ligands displayed d...

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Detalhes bibliográficos
Main Authors: Ligneau, X, Morisset, S, Tardivel-Lacombe, J, Gbahou, F, Ganellin, C R, Stark, H, Schunack, W, Schwartz, J -C, Arrang, J -M
Formato: Artigo
Idioma:Inglês
Publicado em: 2000
Assuntos:
Special Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572469/
https://ncbi.nlm.nih.gov/pubmed/11090094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703712
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