Distinct pharmacology of rat and human histamine H(3) receptors: role of two amino acids in the third transmembrane domain

Starting from the sequence of the human histamine H(3) receptor (hH(3)R) cDNA, we have cloned the corresponding rat cDNA. Whereas the two deduced proteins show 93.5% overall homology and differ only by five amino acid residues at the level of the transmembrane domains (TMs), some ligands displayed d...

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Bibliografiske detaljer
Main Authors: Ligneau, X, Morisset, S, Tardivel-Lacombe, J, Gbahou, F, Ganellin, C R, Stark, H, Schunack, W, Schwartz, J -C, Arrang, J -M
Format: Artigo
Sprog:Inglês
Udgivet: 2000
Fag:
Special Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1572469/
https://ncbi.nlm.nih.gov/pubmed/11090094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0703712
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