Protean agonism at histamine H(3) receptors in vitro and in vivo

G protein-coupled receptors (GPCRs) are allosteric proteins that adopt inactive (R) and active (R(*)) conformations in equilibrium. R(*) is promoted by agonists or occurs spontaneously, leading to constitutive activity of the receptor. Conversely, inverse agonists promote R and decrease constitutive...

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Detalhes bibliográficos
Main Authors: Gbahou, Florence, Rouleau, Agnès, Morisset, Séverine, Parmentier, Régis, Crochet, Sylvain, Lin, Jian-Sheng, Ligneau, Xavier, Tardivel-Lacombe, Joël, Stark, Holger, Schunack, Walter, Ganellin, C. Robin, Schwartz, Jean-Charles, Arrang, Jean-Michel
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC196931/
https://ncbi.nlm.nih.gov/pubmed/12960366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1932276100
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