Mechanism of cytotoxicity of 5,10-dideazatetrahydrofolic acid in human ovarian carcinoma cells in vitro and modulation of the drug activity by folic or folinic acid.

Inhibition of clonogenic potential by the glycinamideribonucleosyl transformylase inhibitor 5,10-dideazatetrahydrofolic acid (DDATHF, Lometrexol) was evaluated in vitro in a human ovarian carcinoma cell line, SW626. Drug-induced inhibition of clonogenic potential is a function of the dose and time o...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Erba, E., Sen, S., Sessa, C., Vikhanskaya, F. L., D'Incalci, M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group 1994
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1968679/
https://ncbi.nlm.nih.gov/pubmed/8297715
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk