Mechanism of cytotoxicity of 5,10-dideazatetrahydrofolic acid in human ovarian carcinoma cells in vitro and modulation of the drug activity by folic or folinic acid.

Inhibition of clonogenic potential by the glycinamideribonucleosyl transformylase inhibitor 5,10-dideazatetrahydrofolic acid (DDATHF, Lometrexol) was evaluated in vitro in a human ovarian carcinoma cell line, SW626. Drug-induced inhibition of clonogenic potential is a function of the dose and time o...

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Main Authors: Erba, E., Sen, S., Sessa, C., Vikhanskaya, F. L., D'Incalci, M.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 1994
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1968679/
https://ncbi.nlm.nih.gov/pubmed/8297715
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