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Selectivity and proofreading both contribute significantly to the fidelity of RNA polymerase III transcription

We examine here the mechanisms ensuring the fidelity of RNA synthesis by RNA polymerase III (Pol III). Misincorporation could only be observed by using variants of Pol III deficient in the intrinsic RNA cleavage activity. Determination of relative rates of the reactions producing correct and erroneo...

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Autors principals: Alic, Nazif, Ayoub, Nayla, Landrieux, Emilie, Favry, Emmanuel, Baudouin-Cornu, Peggy, Riva, Michel, Carles, Christophe
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1965525/
https://ncbi.nlm.nih.gov/pubmed/17553959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0704116104
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