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Fidelity of DNA synthesis by the Thermococcus litoralis DNA polymerase--an extremely heat stable enzyme with proofreading activity.

We demonstrate that the DNA polymerase isolated from Thermococcus litoralis (VentTM DNA polymerase) is the first thermostable DNA polymerase reported having a 3'----5' proofreading exonuclease activity. This facilitates a highly accurate DNA synthesis in vitro by the polymerase. Mutational...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Mattila, P, Korpela, J, Tenkanen, T, Pitkänen, K
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 1991
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC328798/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1923765/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/19.18.4967
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