The crystal structure of Pyrococcus furiosus ornithine carbamoyltransferase reveals a key role for oligomerization in enzyme stability at extremely high temperatures

The Pyrococcus furiosus (PF) ornithine carbamoyltransferase (OTCase; EC 2.1.3.3) is an extremely heat-stable enzyme that maintains about 50% of its activity after heat treatment for 60 min at 100°C. To understand the molecular basis of thermostability of this enzyme, we have determined its three-dim...

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Détails bibliographiques
Auteurs principaux: Villeret, Vincent, Clantin, Bernard, Tricot, Catherine, Legrain, Christianne, Roovers, Martine, Stalon, Victor, Glansdorff, Nicolas, Van Beeumen, Jozef
Format: Artigo
Langue:Inglês
Publié: The National Academy of Sciences 1998
Sujets:
Biological Sciences
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC19649/
https://ncbi.nlm.nih.gov/pubmed/9501170
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