The crystal structure of Pyrococcus furiosus ornithine carbamoyltransferase reveals a key role for oligomerization in enzyme stability at extremely high temperatures

The Pyrococcus furiosus (PF) ornithine carbamoyltransferase (OTCase; EC 2.1.3.3) is an extremely heat-stable enzyme that maintains about 50% of its activity after heat treatment for 60 min at 100°C. To understand the molecular basis of thermostability of this enzyme, we have determined its three-dim...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Villeret, Vincent, Clantin, Bernard, Tricot, Catherine, Legrain, Christianne, Roovers, Martine, Stalon, Victor, Glansdorff, Nicolas, Van Beeumen, Jozef
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC19649/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9501170/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.6.2801
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