Haloperidol induces the nuclear translocation of phosphatidylinositol 3′-kinase to disrupt Akt phosphorylation in PC12 cells

OBJECTIVE: The antipsychotic drug haloperidol (HAL) has been linked to apoptosis and to inhibition of prosurvival Akt signalling in pheochromocytoma (PC12) and neuronal cell cultures. However, the mechanism involved is unclear. METHODS: We used HAL to induce cytotoxicity in preneuronal PC12 cells. T...

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Hauptverfasser: Dai, Yunxiu, Wei, Zelan, Sephton, Chantelle F., Zhang, Di, Anderson, Deborah H., Mousseau, Darrell D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
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Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1963350/
https://ncbi.nlm.nih.gov/pubmed/17823648
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