Haloperidol induces the nuclear translocation of phosphatidylinositol 3′-kinase to disrupt Akt phosphorylation in PC12 cells

OBJECTIVE: The antipsychotic drug haloperidol (HAL) has been linked to apoptosis and to inhibition of prosurvival Akt signalling in pheochromocytoma (PC12) and neuronal cell cultures. However, the mechanism involved is unclear. METHODS: We used HAL to induce cytotoxicity in preneuronal PC12 cells. T...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Dai, Yunxiu, Wei, Zelan, Sephton, Chantelle F., Zhang, Di, Anderson, Deborah H., Mousseau, Darrell D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1963350/
https://ncbi.nlm.nih.gov/pubmed/17823648
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky