DNA binding controls inactivation and nuclear accumulation of the transcription factor Stat1

Cytokine-dependent gene transcription greatly depends on the tyrosine phosphorylation (“activation”) of Stat proteins at the cell membrane. This rapidly leads to their accumulation in the nucleus by an unknown mechanism. We performed microinjections of recombinant Stat1 protein to show that nuclear...

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Hlavní autoři: Meyer, Thomas, Marg, Andreas, Lemke, Petra, Wiesner, Burkhard, Vinkemeier, Uwe
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2003
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC196254/
https://ncbi.nlm.nih.gov/pubmed/12923054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.268003
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