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DNA binding controls inactivation and nuclear accumulation of the transcription factor Stat1
Cytokine-dependent gene transcription greatly depends on the tyrosine phosphorylation (“activation”) of Stat proteins at the cell membrane. This rapidly leads to their accumulation in the nucleus by an unknown mechanism. We performed microinjections of recombinant Stat1 protein to show that nuclear...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2003
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC196254/ https://ncbi.nlm.nih.gov/pubmed/12923054 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.268003 |
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