Cytokine-induced Paracrystals Prolong the Activity of Signal Transducers and Activators of Transcription (STAT) and Provide a Model for the Regulation of Protein Solubility by Small Ubiquitin-like Modifier (SUMO)

The biological effects of cytokines are mediated by STAT proteins, a family of dimeric transcription factors. In order to elicit transcriptional activity, the STATs require activation by phosphorylation of a single tyrosine residue. Our experiments revealed that fully tyrosine-phosphorylated STAT di...

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Autores principales: Droescher, Mathias, Begitt, Andreas, Marg, Andreas, Zacharias, Martin, Vinkemeier, Uwe
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099690/
https://ncbi.nlm.nih.gov/pubmed/21460228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.235978
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