p27 phosphorylation by Src regulates inhibition of Cyclin E-Cdk2 and p27 proteolysis

p27(Kip1) regulates G1 in normal and malignant cells. We present data that Src regulates p27 stability through phosphorylation of p27 at tyrosine 74 and tyrosine 88. Src-phosphorylated p27 inhibits cyclin E-Cdk2 poorly in vitro and Src transfection reduces cyclin E-Cdk2-bound p27. cSrc activation an...

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Main Authors: Chu, Isabel, Sun, Jun, Arnaout, Angel, Kahn, Harriette, Hanna, Wedad, Narod, Steven, Sun, Ping, Tan, Cheng-Keat, Hengst, Ludger, Slingerland, Joyce
Format: Artigo
Jezik:Inglês
Izdano: 2007
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1961623/
https://ncbi.nlm.nih.gov/pubmed/17254967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2006.11.049
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