Physical and functional interactions between polo kinase and the spindle pole component Cut12 regulate mitotic commitment in S. pombe

Commitment to mitosis is regulated by a protein kinase complex called MPF. MPF is inhibited by Wee1-related kinases and activated by Cdc25 phosphatase. MPF activation further boosts Cdc25 and represses Wee1. This feedback control probably involves polo kinase. A dominant cut12.s11 mutation in the Sc...

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Detalhes bibliográficos

Publicado no:	Genes Dev
Principais autores:	MacIver, Fiona H., Tanaka, Kayoko, Robertson, Alasdair M., Hagan, Iain M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Cold Spring Harbor Laboratory Press 2003
Assuntos:	Research Papers
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC196081/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12815070/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.256003
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