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Physical and functional interactions between polo kinase and the spindle pole component Cut12 regulate mitotic commitment in S. pombe
Commitment to mitosis is regulated by a protein kinase complex called MPF. MPF is inhibited by Wee1-related kinases and activated by Cdc25 phosphatase. MPF activation further boosts Cdc25 and represses Wee1. This feedback control probably involves polo kinase. A dominant cut12.s11 mutation in the Sc...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Cold Spring Harbor Laboratory Press
2003
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC196081/ https://ncbi.nlm.nih.gov/pubmed/12815070 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.256003 |
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