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Physical and functional interactions between polo kinase and the spindle pole component Cut12 regulate mitotic commitment in S. pombe

Commitment to mitosis is regulated by a protein kinase complex called MPF. MPF is inhibited by Wee1-related kinases and activated by Cdc25 phosphatase. MPF activation further boosts Cdc25 and represses Wee1. This feedback control probably involves polo kinase. A dominant cut12.s11 mutation in the Sc...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MacIver, Fiona H., Tanaka, Kayoko, Robertson, Alasdair M., Hagan, Iain M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2003
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC196081/
https://ncbi.nlm.nih.gov/pubmed/12815070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.256003
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