The β-globin locus control region (LCR) functions primarily by enhancing the transition from transcription initiation to elongation

To investigate the molecular basis of β-globin gene activation, we analyzed factor recruitment and histone modification at the adult β-globin gene in wild-type (WT)/locus control region knockout (ΔLCR) heterozygous mice and in murine erythroleukemia (MEL) cells. Although histone acetylation and meth...

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Detalles Bibliográficos

Publicado en:	Genes Dev
Autores principales:	Sawado, Tomoyuki, Halow, Jessica, Bender, M.A., Groudine, Mark
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Cold Spring Harbor Laboratory Press 2003
Materias:	Research Paper
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC196035/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12672691/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1072303
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