Proapoptotic BID is required for myeloid homeostasis and tumor suppression

The proper expansion and contraction of hematopoietic cells requires tight regulation of cell death. BID, a “BH3-only” molecule, amplifies death receptor signals connecting the extrinsic to intrinsic pathways by triggering the mitochondrial pathway of apoptosis. Bid-deficient mice, as they age, spon...

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Bibliografiska uppgifter
Huvudupphovsmän: Zinkel, Sandra S., Ong, Christy C., Ferguson, David O., Iwasaki, Hiromi, Akashi, Koichi, Bronson, Roderick T., Kutok, Jeffery L., Alt, Frederick W., Korsmeyer, Stanley J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 2003
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC195974/
https://ncbi.nlm.nih.gov/pubmed/12533511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1045603
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