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Proapoptotic BID is required for myeloid homeostasis and tumor suppression

The proper expansion and contraction of hematopoietic cells requires tight regulation of cell death. BID, a “BH3-only” molecule, amplifies death receptor signals connecting the extrinsic to intrinsic pathways by triggering the mitochondrial pathway of apoptosis. Bid-deficient mice, as they age, spon...

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Udgivet i:Genes Dev
Principais autores: Zinkel, Sandra S., Ong, Christy C., Ferguson, David O., Iwasaki, Hiromi, Akashi, Koichi, Bronson, Roderick T., Kutok, Jeffery L., Alt, Frederick W., Korsmeyer, Stanley J.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2003
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC195974/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12533511/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1045603
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