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Pax5 is required for recombination of transcribed, acetylated, 5′ IgH V gene segments

Pax5-deficient progenitor B (pro-B) cells are thought to be severely defective for recombination of all immunoglobulin heavy chain (IgH) V gene segments, but the mechanism by which Pax5 regulates this process has not been defined. To address this issue, we have examined the assembly of the IgH locus...

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Udgivet i:Genes Dev
Principais autores: Hesslein, David G.T., Pflugh, David L., Chowdhury, Dipanjan, Bothwell, Alfred L. M., Sen, Ranjan, Schatz, David G.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2003
Fag:
Research Communication
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC195966/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12514097/
https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1031403
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