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Models of β-Amyloid Ion Channels in the Membrane Suggest That Channel Formation in the Bilayer Is a Dynamic Process

Here we model the Alzheimer β-peptide ion channel with the goal of obtaining insight into the mechanism of amyloid toxicity. The models are built based on NMR data of the oligomers, with the universal U-shaped (strand-turn-strand) motif. After 30-ns simulations in the bilayer, the channel dimensions...

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Détails bibliographiques
Auteurs principaux: Jang, Hyunbum, Zheng, Jie, Nussinov, Ruth
Format: Artigo
Langue:Inglês
Publié: Biophysical Society 2007
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1959551/
https://ncbi.nlm.nih.gov/pubmed/17526580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.110148
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