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Nucleation and Growth of Insulin Fibrils in Bulk Solution and at Hydrophobic Polystyrene Surfaces

A technique was developed for studying the nucleation and growth of fibrillar protein aggregates. Fourier transform infrared and attenuated total reflection spectroscopy were used to measure changes in the intermolecular β-sheet content of bovine pancreatic insulin in bulk solution and on model poly...

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Bibliografiske detaljer
Main Authors: Smith, M. I., Sharp, J. S., Roberts, C. J.
Format: Artigo
Sprog:Inglês
Udgivet: Biophysical Society 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1959525/
https://ncbi.nlm.nih.gov/pubmed/17496011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.105338
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