Correction of the X-linked immunodeficiency phenotype by transgenic expression of human Bruton tyrosine kinase under the control of the class II major histocompatibility complex Ea locus control region

Bruton tyrosine kinase (Btk) is essential for the development of pre-B cells to mature B cell stages. Btk-deficient mice manifest an X-linked immunodeficiency (xid) defect characterized by a reduction of peripheral IgM(low) IgD(high) B cells, a lack of peritoneal CD5(+) B cells, low serum levels of...

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Main Authors: Drabek, Dubravka, Raguz, Selina, De Wit, Ton P. M., Dingjan, Gemma M., Savelkoul, Huub F. J., Grosveld, Frank, Hendriks, Rudolf W.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences of the USA 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC19561/
https://ncbi.nlm.nih.gov/pubmed/9012832
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