Bruton's Tyrosine Kinase Cooperates with the B Cell Linker Protein SLP-65 as a Tumor Suppressor in Pre-B Cells

Expression of the pre-B cell receptor (pre-BCR) leads to activation of the adaptor molecule SLP-65 and the cytoplasmic kinase Btk. Mice deficient for one of these signaling proteins have an incomplete block in B cell development at the stage of large cycling pre-BCR(+)CD43(+) pre-B cells. Our recent...

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Detalhes bibliográficos
Main Authors: Kersseboom, Rogier, Middendorp, Sabine, Dingjan, Gemma M., Dahlenborg, Katarina, Reth, Michael, Jumaa, Hassan, Hendriks, Rudolf W.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2196076/
https://ncbi.nlm.nih.gov/pubmed/12835482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20030615
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