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Severe B cell deficiency and disrupted splenic architecture in transgenic mice expressing the E41K mutated form of Bruton's tyrosine kinase.

To identify B-cell signaling pathways activated by Bruton's tyrosine kinase (Btk) in vivo, we generated transgenic mice in which Btk expression is driven by the MHC class II Ea gene locus control region. Btk overexpression did not have significant adverse effects on B cell function, and essenti...

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Detalhes bibliográficos
Main Authors: Dingjan, G M, Maas, A, Nawijn, M C, Smit, L, Voerman, J S, Grosveld, F, Hendriks, R W
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1170858/
https://ncbi.nlm.nih.gov/pubmed/9736610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/17.18.5309
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