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Disruption of CXCR4 enhances osteoclastogenesis and tumor growth in bone
CXCR4 regulates hematopoietic and tumor cell homing to bone, but its role during osteoclast (OC) development is unknown. We investigated the role of CXCR4 in osteoclastogenesis and in a model of bone metastasis. Compared with controls, mice reconstituted with CXCR4 null hematopoietic cells exhibited...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1955795/ https://ncbi.nlm.nih.gov/pubmed/17715292 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705203104 |
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