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Molecular Basis for Checkpoints in the CD8 T Cell Response: Tolerance versus Activation

CD8 T cells specific for self-antigens are present in the peripheral lymphoid system and can contribute to autoimmunity or transplant rejection. Whether recognition of Ag leads to full activation, or to induction of tolerance, depends upon availability of cytokine at critical stages of the response....

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Autors principals: Mescher, Matthew F., Agarwal, Pujya, Casey, Kerry A., Hammerbeck, Christopher D., Xiao, Zhengguo, Curtsinger, Julie M.
Format: Artigo
Idioma:Inglês
Publicat: 2007
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1955740/
https://ncbi.nlm.nih.gov/pubmed/17382557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.smim.2007.02.007
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