Urocortin II mediates pro‐inflammatory effects in human colonocytes via corticotropin‐releasing hormone receptor 2α

BACKGROUND/AIMS: Urocortin II (UcnII) is a neuropeptide that binds with high affinity to the corticotropin‐releasing hormone receptor 2 (CRHR2) in peripheral tissues. UcnII is synthesised in the intestine, but its role in human intestinal inflammation is largely unknown. METHODS: Responses of human...

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Detalhes bibliográficos
Main Authors: Moss, Alan C, Anton, Pauline, Savidge, Tor, Newman, Paul, Cheifetz, Adam S, Gay, Jerome, Paraschos, Sophia, Winter, Michael Weinstein, Moyer, Mary P, Karalis, Katia, Kokkotou, Efi, Pothoulakis, Charalabos
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Group 2007
Assuntos:
Neurogastroenterology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1954994/
https://ncbi.nlm.nih.gov/pubmed/17412781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gut.2006.110668
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